' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 58 Researches
7.2
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Soft Gel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
1%**
Cholesterol
<5mg
<2%
Vitamin A (from cod live oil and retinyl palmitate)
27 mcg RAE
3%
Vitamin D (as cholecalciferol) (from cod liver oil and cholecalciferol concentrate)
100 mcg (4,000 IU)
500%
Vitamin E (as d-alpha tocopherol)
0.67 mg
4%
Norwegian Cod Liver Oil
500 mg
†
Total Omega-3 fatty Acids☆
115 mg
†
DHA (Docosahexaenoic Acid)☆
50 mg
†
EPA (Eicosapentaenoic Acid)☆
42 mg
†
Top Medical Research Studies
9
Cod liver oil and heart health
Fish oil, atherogenesis, and thrombogenesis.
Strong relevance to cardiovascular effects
We examined how cod liver oil might influence cardiovascular disease, particularly in relation to atherogenesis and thrombogenesis. Previous observations suggested that eating marine fish can lower the risk of ischemic heart disease. However, the universal recommendation for fish oil as a supplement remains uncertain due to potential side effects associated with high dosages.
Our research revealed that while fish oil lowers cholesterol and triglyceride levels, it can also increase levels of low-density lipoprotein, which raises concerns about free radical generation and bleeding. Interestingly, moderate intake of marine fish has shown protective effects against heart disease without significantly changing traditional measurements like cholesterol levels or blood clotting times.
In a controlled study with swine, we noted that adding cod liver oil to a high-fat diet resulted in fewer monocyte adhesions and platelet clumps in critical heart arteries, suggesting that it plays a role in reducing clotting risks. To delve deeper into the mechanisms, we conducted an in vitro experiment where we treated endothelial cells with varying fatty acids.
Among these, only eicosapentaenoic acid (EPA) stood out in diminishing the binding of human monocytes to the endothelial cells, especially when applied within a specific timeframe after stimulation. Moreover, we found that EPA decreased the expression of certain adhesion molecules on endothelial cells following inflammatory stimulation.
Overall, our findings suggest that cod liver oil could be a potentially valuable addition to heart health strategies, particularly due to its unique ability to influence blood vessel interactions without significant adverse effects.
Our research revealed that while fish oil lowers cholesterol and triglyceride levels, it can also increase levels of low-density lipoprotein, which raises concerns about free radical generation and bleeding. Interestingly, moderate intake of marine fish has shown protective effects against heart disease without significantly changing traditional measurements like cholesterol levels or blood clotting times.
In a controlled study with swine, we noted that adding cod liver oil to a high-fat diet resulted in fewer monocyte adhesions and platelet clumps in critical heart arteries, suggesting that it plays a role in reducing clotting risks. To delve deeper into the mechanisms, we conducted an in vitro experiment where we treated endothelial cells with varying fatty acids.
Among these, only eicosapentaenoic acid (EPA) stood out in diminishing the binding of human monocytes to the endothelial cells, especially when applied within a specific timeframe after stimulation. Moreover, we found that EPA decreased the expression of certain adhesion molecules on endothelial cells following inflammatory stimulation.
Overall, our findings suggest that cod liver oil could be a potentially valuable addition to heart health strategies, particularly due to its unique ability to influence blood vessel interactions without significant adverse effects.
Read More
9
Vitamin D reduces foam cell formation
Vitamin D reduces VSMC foam cell formation and protects against AS progression.
Highly relevant to cardiovascular management
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
9
Cod liver oil aids diabetic heart health
Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats.
Direct effect of CLO on diabetes
We explored the effects of cod liver oil (CLO) on cardiovascular health in rats with diabetes, particularly how it might improve various related issues. In our study, diabetic rats were treated with CLO for 12 weeks and we compared their health with untreated diabetic rats.
Results showed that CLO treatment led to notable improvements. It helped prevent weight loss and completely corrected the abnormal lipid levels found in these diabetic rats. While it didn't fully normalize blood sugar levels, it did help control them partially, which is a positive step.
We also examined how CLO impacted the heart and blood vessels. The oil improved the functioning of blood vessels, alleviating some of the vasoconstriction caused by diabetes and restoring endothelial function. Moreover, CLO helped normalize heart contractions and responses to certain stimuli, suggesting better heart health.
Overall, we found that cod liver oil supplementation effectively targets cardiovascular issues linked to diabetes in these experimental models, making it a promising area for future research.
Results showed that CLO treatment led to notable improvements. It helped prevent weight loss and completely corrected the abnormal lipid levels found in these diabetic rats. While it didn't fully normalize blood sugar levels, it did help control them partially, which is a positive step.
We also examined how CLO impacted the heart and blood vessels. The oil improved the functioning of blood vessels, alleviating some of the vasoconstriction caused by diabetes and restoring endothelial function. Moreover, CLO helped normalize heart contractions and responses to certain stimuli, suggesting better heart health.
Overall, we found that cod liver oil supplementation effectively targets cardiovascular issues linked to diabetes in these experimental models, making it a promising area for future research.
Read More
Most Useful Reviews
9.5
Strengthens immune system
The Vitamin Complex Solar D Gems from Carlson Labs includes vitamin D3, Omega-3 fatty acids, and vitamins A and E. The Omega-3s help my cardiovascular health, brain function, and cholesterol levels. I highly recommend this supplement for overall health as it boosts immunity and aids in managing cardiovascular disease.
Read More
8.8
Supports cardiovascular health
It is very convenient to have a year’s supply of capsules in one jar, allowing me to focus on my health without worrying about reordering. The 4000 IU dosage is ideal for maintaining my vitamin D levels, and the small capsules are easy to swallow. Importantly, the inclusion of Omega-3, and vitamins A and E, supports my immunity and cardiovascular disease health.
Read More
8.8
Promotes bone health
This D3 supplement with Omega from cod liver is excellent for absorption. It supports bone health and is beneficial for the cardiovascular disease system. The dosage is good, and the brand consistently provides top quality.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 58 Researches
7.2
9
Vitamin D reduces foam cell formation
Vitamin D reduces VSMC foam cell formation and protects against AS progression.
Highly relevant to cardiovascular management
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
9
DHA supports heart recovery post-MI
Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway.
Focus on DHA, not cod liver oil
We explored the effects of docosahexaenoic acid (DHA), a fatty acid found in cod liver oil, on heart health after a heart attack, known as myocardial infarction (MI). Using both lab-grown heart cells and mouse models, we investigated how DHA might protect against heart damage following an MI.
Our findings revealed that DHA significantly improved the survival of heart cells under stress and reduced damage in mouse hearts after MI. It not only decreased the size of heart tissue damage but also enhanced overall heart function and lowered fibrosis, which is the scarring of heart tissue.
In addition to these protective effects, we observed that DHA boosted autophagy, a process that helps cells clear out damaged components, and reduced cell death. We further noted that DHA promotes this beneficial process through the activation of the AMPK/mTOR signaling pathway, which is crucial for regulating cell energy and growth.
This study highlights the powerful cardiovascular benefits of DHA, suggesting that it could be a valuable component of heart health, particularly in supporting recovery after heart attacks.
Our findings revealed that DHA significantly improved the survival of heart cells under stress and reduced damage in mouse hearts after MI. It not only decreased the size of heart tissue damage but also enhanced overall heart function and lowered fibrosis, which is the scarring of heart tissue.
In addition to these protective effects, we observed that DHA boosted autophagy, a process that helps cells clear out damaged components, and reduced cell death. We further noted that DHA promotes this beneficial process through the activation of the AMPK/mTOR signaling pathway, which is crucial for regulating cell energy and growth.
This study highlights the powerful cardiovascular benefits of DHA, suggesting that it could be a valuable component of heart health, particularly in supporting recovery after heart attacks.
Read More
9
Cod liver oil aids diabetic heart health
Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats.
Direct effect of CLO on diabetes
We explored the effects of cod liver oil (CLO) on cardiovascular health in rats with diabetes, particularly how it might improve various related issues. In our study, diabetic rats were treated with CLO for 12 weeks and we compared their health with untreated diabetic rats.
Results showed that CLO treatment led to notable improvements. It helped prevent weight loss and completely corrected the abnormal lipid levels found in these diabetic rats. While it didn't fully normalize blood sugar levels, it did help control them partially, which is a positive step.
We also examined how CLO impacted the heart and blood vessels. The oil improved the functioning of blood vessels, alleviating some of the vasoconstriction caused by diabetes and restoring endothelial function. Moreover, CLO helped normalize heart contractions and responses to certain stimuli, suggesting better heart health.
Overall, we found that cod liver oil supplementation effectively targets cardiovascular issues linked to diabetes in these experimental models, making it a promising area for future research.
Results showed that CLO treatment led to notable improvements. It helped prevent weight loss and completely corrected the abnormal lipid levels found in these diabetic rats. While it didn't fully normalize blood sugar levels, it did help control them partially, which is a positive step.
We also examined how CLO impacted the heart and blood vessels. The oil improved the functioning of blood vessels, alleviating some of the vasoconstriction caused by diabetes and restoring endothelial function. Moreover, CLO helped normalize heart contractions and responses to certain stimuli, suggesting better heart health.
Overall, we found that cod liver oil supplementation effectively targets cardiovascular issues linked to diabetes in these experimental models, making it a promising area for future research.
Read More
9
Cod liver oil and heart health
Fish oil, atherogenesis, and thrombogenesis.
Strong relevance to cardiovascular effects
We examined how cod liver oil might influence cardiovascular disease, particularly in relation to atherogenesis and thrombogenesis. Previous observations suggested that eating marine fish can lower the risk of ischemic heart disease. However, the universal recommendation for fish oil as a supplement remains uncertain due to potential side effects associated with high dosages.
Our research revealed that while fish oil lowers cholesterol and triglyceride levels, it can also increase levels of low-density lipoprotein, which raises concerns about free radical generation and bleeding. Interestingly, moderate intake of marine fish has shown protective effects against heart disease without significantly changing traditional measurements like cholesterol levels or blood clotting times.
In a controlled study with swine, we noted that adding cod liver oil to a high-fat diet resulted in fewer monocyte adhesions and platelet clumps in critical heart arteries, suggesting that it plays a role in reducing clotting risks. To delve deeper into the mechanisms, we conducted an in vitro experiment where we treated endothelial cells with varying fatty acids.
Among these, only eicosapentaenoic acid (EPA) stood out in diminishing the binding of human monocytes to the endothelial cells, especially when applied within a specific timeframe after stimulation. Moreover, we found that EPA decreased the expression of certain adhesion molecules on endothelial cells following inflammatory stimulation.
Overall, our findings suggest that cod liver oil could be a potentially valuable addition to heart health strategies, particularly due to its unique ability to influence blood vessel interactions without significant adverse effects.
Our research revealed that while fish oil lowers cholesterol and triglyceride levels, it can also increase levels of low-density lipoprotein, which raises concerns about free radical generation and bleeding. Interestingly, moderate intake of marine fish has shown protective effects against heart disease without significantly changing traditional measurements like cholesterol levels or blood clotting times.
In a controlled study with swine, we noted that adding cod liver oil to a high-fat diet resulted in fewer monocyte adhesions and platelet clumps in critical heart arteries, suggesting that it plays a role in reducing clotting risks. To delve deeper into the mechanisms, we conducted an in vitro experiment where we treated endothelial cells with varying fatty acids.
Among these, only eicosapentaenoic acid (EPA) stood out in diminishing the binding of human monocytes to the endothelial cells, especially when applied within a specific timeframe after stimulation. Moreover, we found that EPA decreased the expression of certain adhesion molecules on endothelial cells following inflammatory stimulation.
Overall, our findings suggest that cod liver oil could be a potentially valuable addition to heart health strategies, particularly due to its unique ability to influence blood vessel interactions without significant adverse effects.
Read More
9
Docosahexaenoic acid improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
Addresses omega-3 dosage effectiveness
We conducted a network meta-analysis to investigate the effects of docosahexaenoic acid, an omega-3 fatty acid, on heart failure management. By examining various randomized controlled trials, we aimed to understand how different dosages and durations of supplementation impact heart function.
Our findings revealed that high-dose supplementation—ranging from 2000 to 4000 mg per day—over more than one year significantly improved heart function, particularly left ventricular ejection fraction and peak oxygen consumption. This indicates a promising role for docosahexaenoic acid in enhancing cardiovascular health in patients dealing with heart failure.
However, we also noted that lower doses and shorter treatment periods did not yield the same benefits. Importantly, the analysis showed no significant increase in dropout rates or all-cause mortality associated with omega-3 supplementation when compared to control groups.
Overall, the evidence suggests that long-term, high-dose docosahexaenoic acid supplementation can positively influence heart function without heightened risk. Future research should focus on more rigorous trials to further validate these findings and address any biases.
Our findings revealed that high-dose supplementation—ranging from 2000 to 4000 mg per day—over more than one year significantly improved heart function, particularly left ventricular ejection fraction and peak oxygen consumption. This indicates a promising role for docosahexaenoic acid in enhancing cardiovascular health in patients dealing with heart failure.
However, we also noted that lower doses and shorter treatment periods did not yield the same benefits. Importantly, the analysis showed no significant increase in dropout rates or all-cause mortality associated with omega-3 supplementation when compared to control groups.
Overall, the evidence suggests that long-term, high-dose docosahexaenoic acid supplementation can positively influence heart function without heightened risk. Future research should focus on more rigorous trials to further validate these findings and address any biases.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
Strengthens immune system
The Vitamin Complex Solar D Gems from Carlson Labs includes vitamin D3, Omega-3 fatty acids, and vitamins A and E. The Omega-3s help my cardiovascular health, brain function, and cholesterol levels. I highly recommend this supplement for overall health as it boosts immunity and aids in managing cardiovascular disease.
Read More
8.8
Supports cardiovascular health
It is very convenient to have a year’s supply of capsules in one jar, allowing me to focus on my health without worrying about reordering. The 4000 IU dosage is ideal for maintaining my vitamin D levels, and the small capsules are easy to swallow. Importantly, the inclusion of Omega-3, and vitamins A and E, supports my immunity and cardiovascular disease health.
Read More
8.8
Promotes bone health
This D3 supplement with Omega from cod liver is excellent for absorption. It supports bone health and is beneficial for the cardiovascular disease system. The dosage is good, and the brand consistently provides top quality.
8.8
Supports heart function
The high-quality Omega and vitamin D3 are perfect for maintaining my cardiovascular health, skin, immune system, and nervous function. This supplement lowers cholesterol, features a natural composition, and has a pleasant lemon taste. The large packaging holds a substantial amount, providing excellent value.
Read More
8
Eases bone pain
I found this supplement beneficial as I take one capsule daily for a year’s worth. Containing vitamins A, D3, and cod liver oil, it has significantly reduced my joint pain associated with my profession, which involves vibration, while also aiding in cardiovascular disease.
